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Den viktigste årsaken er sannsynligvis at petidinmetabolitten norpetidin akkumuleres hos barnet (fig 1). Hvis det er indikasjon for å gi sterke opioidanalgetika, bør derfor morfin foretrekkes fremfor petidin. Det er også en risiko for serotonerge bivirkninger, inkludert serotonergt syndrom. Dette oppstår sjelden og da når minst to legemidler